Imaging and Modulating Antisense Microdistribution in Solid Human Xenograft Tumor Models
نویسندگان
چکیده
منابع مشابه
Imaging and modulating antisense microdistribution in solid human xenograft tumor models.
PURPOSE The tumor microenvironment is complex and heterogeneous, populated by tortuous irregular vasculature, hypoxic cells, and necrotic regions. These factors can all contribute to the biodistribution difficulties encountered by most cancer therapeutic agents. Antisense oligodeoxynucleotides (ASO) are a class of therapeutics where limited information is available about their distribution with...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2007
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-06-3085